Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals

Author:

Matsumoto JunyaORCID,Fukunaga MasakiORCID,Miura KenichiroORCID,Nemoto KiyotakaORCID,Okada Naohiro,Hashimoto Naoki,Morita Kentaro,Koshiyama Daisuke,Ohi KazutakaORCID,Takahashi TsutomuORCID,Koeda MichihikoORCID,Yamamori Hidenaga,Fujimoto Michiko,Yasuda Yuka,Ito SatsukiORCID,Yamazaki Ryuichi,Hasegawa Naomi,Narita HisashiORCID,Yokoyama SatoshiORCID,Mishima Ryo,Miyata JunORCID,Kobayashi Yuko,Sasabayashi DaikiORCID,Harada Kenichiro,Yamamoto Maeri,Hirano Yoji,Itahashi Takashi,Nakataki Masahito,Hashimoto Ryu-ichiroORCID,Tha Khin K.ORCID,Koike Shinsuke,Matsubara Toshio,Okada Go,Yoshimura Reiji,Abe OsamuORCID,van Erp Theo G. M.,Turner Jessica A.,Jahanshad Neda,Thompson Paul M.,Onitsuka Toshiaki,Watanabe Yoshiyuki,Matsuo Koji,Yamasue HidenoriORCID,Okamoto Yasumasa,Suzuki Michio,Ozaki NorioORCID,Kasai KiyotoORCID,Hashimoto RyotaORCID

Abstract

AbstractAccording to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder (ASD) are classified based on symptoms. While its cluster of symptoms defines each of these psychiatric disorders, there is also an overlap in symptoms between the disorders. We hypothesized that there are also similarities and differences in cortical structural neuroimaging features among these psychiatric disorders. T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects recruited from 14 sites. Effect sizes were determined using a linear regression model within each protocol, and these effect sizes were meta-analyzed. The similarity of the differences in cortical thickness and surface area of each disorder group was calculated using cosine similarity, which was calculated from the effect sizes of each cortical regions. The thinnest cortex was found in SZ, followed by BD and MDD. The cosine similarity values between disorders were 0.943 for SZ and BD, 0.959 for SZ and MDD, and 0.943 for BD and MDD, which indicated that a common pattern of cortical thickness alterations was found among SZ, BD, and MDD. Additionally, a generally smaller cortical surface area was found in SZ and MDD than in BD, and the effect was larger in SZ. The cosine similarity values between disorders were 0.945 for SZ and MDD, 0.867 for SZ and ASD, and 0.811 for MDD and ASD, which indicated a common pattern of cortical surface area alterations among SZ, MDD, and ASD. Patterns of alterations in cortical thickness and surface area were revealed in the four major psychiatric disorders. To our knowledge, this is the first report of a cross-disorder analysis conducted on four major psychiatric disorders. Cross-disorder brain imaging research can help to advance our understanding of the pathogenesis of psychiatric disorders and common symptoms.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

National Center of Neurology and Psychiatry

SENSHIN Medical Research Foundation

MEXT | Japan Science and Technology Agency

UTokyo Institute for Diversity and Adaptation of Human Mind (UTIDAHM) the International Research Center for Neurointelligence (WPI-IRCN) at The University of Tokyo Institutes for Advanced Study

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Molecular Biology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3