Advances in targeting ‘undruggable’ transcription factors with small molecules
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://www.nature.com/articles/s41573-021-00199-0.pdf
Reference290 articles.
1. Lambert, S. A. et al. The human transcription factors. Cell 172, 650–665 (2018).
2. Vernimmen, D. & Bickmore, W. A. The hierarchy of transcriptional activation: from enhancer to promoter. Trends Genet. 31, 696–708 (2015).
3. Lee, T. I. & Young, R. A. Transcriptional regulation and its misregulation in disease. Cell 152, 1237–1251 (2013). This review is a valuable reference for understanding the mechanisms by which transcription is dysregulated in disease.
4. Brivanlou, A. H. & Darnell, J. E. Signal transduction and the control of gene expression. Science 295, 813–818 (2002).
5. Darnell, J. E. Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2, 740–749 (2002).
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