Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass-Reference-Cited by-同舟云学术

Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass

Published:2006-04-23 Issue:5 Volume:38 Page:589-593
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Hashimoto Naoko,Kido Yoshiaki,Uchida Tohru,Asahara Shun-ichiro,Shigeyama Yutaka,Matsuda Tomokazu,Takeda Akihiko,Tsuchihashi Daisuke,Nishizawa Akihiko,Ogawa Wataru,Fujimoto Yoshito,Okamura Hitoshi,Arden Karen C,Herrera Pedro L,Noda Tetsuo,Kasuga Masato

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng1774.pdf

Reference28 articles.

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2. Kulkarni, R.N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329–339 (1999).

3. Withers, D.J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900–904 (1998).

4. Kubota, N. et al. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia. Diabetes 49, 1880–1889 (2000).

5. Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728–1731 (2001).

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