Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis-Reference-Cited by-同舟云学术

Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis

Published:2002-10-15 Issue:11 Volume:8 Page:1263-1269
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

McLaurin J.,Cecal R.,Kierstead M.E.,Tian X.,Phinney A.L.,Manea M.,French J.E.,Lambermon M.H.L.,Darabie A.A.,Brown M.E.,Janus C.,Chishti M.A.,Horne P.,Westaway D.,Fraser P.E.,Mount H.T.J.,Przybylski M.,St George-Hyslop P.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm790.pdf

Reference36 articles.

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2. Chishti, M.A. et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J. Biol. Chem. 276, 21562–21570 (2001).

3. Janus, C. et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408, 979–982 (2000).

4. Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173–177 (1999).

5. Morgan, D. et al. Vaccination with Aβ peptide prevents memory deficits in an animal model of Alzheimer's disease. Nature 408, 982–985 (2000).

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