Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

Author:

Ram Zvi,Culver Kenneth W.,Oshiro Eric M.,Viola John J.,DeVroom Hetty L.,Otto Edward,Long Zhifeng,Chiang Yawen,McGarrity Gerard J.,Muul Linda M.,Katz David,Michael Blaese R.,Oldfield Edward H.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference29 articles.

1. Barba, D., Hardin, J., Ray, J. & Gage, F.H. Thymidine kinase-mediated killing of rat brain tumors. J. Neurosurg. 79, 729–735 (1993).

2. Culver, K.W. et al. In vivo gene transfer with retroviral vector-producing cells for treatment of experimental brain tumors. Science 256, 1550–1552 (1992).

3. Ezzeddine, Z.D. et al. Selective killing of glioma Cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol. 3, 608–614 (1991).

4. Caruso, M. et al. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA 90, 7024–7028 (1993).

5. Moolten, F.L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276–5281 (1986).

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