NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia-Reference-Cited by-同舟云学术

NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia

Published:2018-09-10 Issue:12 Volume:32 Page:2527-2535
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Tulstrup Morten^ORCID,Grosjean Marie,Nielsen Stine Nygaard,Grell Kathrine,Wolthers Benjamin Ole,Wegener Peder Skov,Jonsson Olafur Gisli,Lund Bendik,Harila-Saari Arja,Abrahamsson Jonas,Vaitkeviciene Goda,Pruunsild Kaie,Toft Nina,Holm Mette,Hulegårdh Erik,Liestøl Sigurd,Griskevicius Laimonas,Punab Mari,Wang Jinhua,Carroll William L.,Zhang Zeyu,Dalgaard Marlene D.,Gupta Ramneek,Nersting Jacob,Schmiegelow Kjeld

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/s41375-018-0245-3.pdf

Reference38 articles.

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3. Balis FM, Holcenberg JS, Poplack DG, Ge J, Sather HN, Murphy RF, et al. Pharmacokinetics and pharmacodynamics of oral methotrexate and mercaptopurine in children with lower risk acute lymphoblastic leukemia: a Joint Children’s Cancer Group and Pediatric Oncology Branch Study. Blood. 1998;92:3569–77.

4. Karran P. Thiopurines, DNA damage, DNA repair and therapy-related cancer. Br Med Bull. 2006;79–80:153–70.

5. Schmiegelow K, Nielsen SN, Frandsen TL, Nersting J. Mercaptopurine/methotrexate maintenance therapy of childhood acute lymphoblastic leukemia: clinical facts and fiction. J Pediatr Hematol Oncol. 2014;36:503–17.

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