Bortezomib/bendamustine/dexamethasone induced good PR in refractory relapse post auto-SCT with constitutive RAS activation due to V600E BRAF mutation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Transplantation,Hematology
Link
http://www.nature.com/articles/bmt2014192.pdf
Reference14 articles.
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2. Mulligan G, Lichter DI, Di Bacco A, Blakemore SJ, Berger A, Koenig E et al. Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy. Blood 2014; 123: 632.
3. Ramakrishnan V, Timm M, Haug J, Kimlinger T, Wellik L, Witzig T et al. Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene 2010; 29: 1190.
4. Chim CS, Hwang YY, Pang C, Shek TW . Restoration of chemosensitivity by bortezomib: implications for refractory myeloma. Nat Rev Clin Oncol 2009; 6: 237.
5. Chim CS, Lie AK, Chan EY, Liu HS, Lau C, Yip S et al. Treatment outcome and prognostic factor analysis in transplant-eligible Chinese myeloma patients receiving bortezomib-based induction regimens including the staged approach, PAD or VTD. J Hematol Oncol 2012; 5: 28.
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1. Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma;Scientific Reports;2018-09-10
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