Computationally designed antibody–drug conjugates self-assembled via affinity ligands
Author:
Publisher
Springer Science and Business Media LLC
Subject
Computer Science Applications,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Link
http://www.nature.com/articles/s41551-019-0470-8.pdf
Reference52 articles.
1. Beck, A. et al. Strategies and challenges for the next generation of antibody drug conjugates. Nat. Rev. Drug Discov. 16, 315–337 (2017).
2. Gordon, M. R. et al. Field guide to challenges and opportunities in antibody-drug conjugates for chemists. Bioconjug. Chem. 26, 2198–2215 (2015).
3. Axup, J. Y. et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc. Natl Acad. Sci. USA 109, 16101–16106 (2012).
4. Junutula, J. R. et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat. Biotechnol. 26, 925–932 (2008).
5. Jeger, S. et al. Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase. Angew. Chemie Int. Ed. 49, 9995–9997 (2010).
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