NAD+ metabolism and its roles in cellular processes during ageing
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/s41580-020-00313-x.pdf
Reference272 articles.
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2. Cambronne, X. A. & Kraus, W. L. Location, location, location: compartmentalization of NAD synthesis and functions in mammalian cells. Trends Biochem. Sci. 45, 858–873 (2020).
3. Verdin, E. NAD+ in aging, metabolism, and neurodegeneration. Science 350, 1208–1213 (2015).
4. Cambronne, X. A. et al. Biosensor reveals multiple sources for mitochondrial NAD+. Science 352, 1474–1477 (2016).
5. Liu, L. et al. Quantitative analysis of NAD synthesis-breakdown fluxes. Cell Metab. 27, 1067–1080.e5 (2018). This study demonstrates that NAD+ synthesis breakdown fluxes differ widely across tissues, suggesting a tissue-specific NAD+ metabolism.
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