Neutralizing antibodies do not fully explain SARS-CoV-2 protective immunity

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Springer Science and Business Media LLC

Reference5 articles.

1. Gilbert, P. B. et al. A Covid-19 milestone attained — a correlate of protection for vaccines. N. Engl. J. Med. 387, 22032206 (2022). A prospective article that summarizes the success of establishing a SARS-CoV-2 correlate of protection before the emergence of immune-evasive variants.

2. Mettelman, R. C. et al. Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology. Nat. Immunol. 24, 1511–1526 (2023). This paper reports the contribution of innate and adaptive cellular responses, as well as pre-existing antibodies, to protection against influenza virus.

3. Cohen, C. et al. Asymptomatic transmission and high community burden of seasonal influenza in an urban and a rural community in South Africa, 2017–18 (PHIRST): a population cohort study. Lancet Glob. Health 9, e863–e874 (2021). This paper reports the pre-pandemic PHIRST cohort infrastructure that this study relies on.

4. Cowling, B. J. et al. Influenza hemagglutination-inhibition antibody titer as a mediator of vaccine-induced protection for influenza B. Clin. Infect. Dis. 68, 1713–1717 (2019). A pioneer study adopting mediation analysis to understand correlates of protection against influenza B virus.

5. Halloran, M. E. & Struchiner, C. J. Causal inference in infectious diseases. Epidemiology 6, 142–151 (1995). A seminal paper that proposed using transmission probability as a causal estimand for causal inference in infectious disease.

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