Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan-Reference-Cited by-同舟云学术

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Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

Published:2020-03-23 Issue:4 Volume:26 Page:542-548
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Sakaue Saori^ORCID, ,Kanai Masahiro^ORCID,Karjalainen Juha,Akiyama Masato,Kurki Mitja,Matoba Nana^ORCID,Takahashi Atsushi^ORCID,Hirata Makoto,Kubo Michiaki,Matsuda Koichi,Murakami Yoshinori,Daly Mark J.^ORCID,Kamatani Yoichiro^ORCID,Okada Yukinori^ORCID

Funder

MEXT | Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Takeda Science Foundation Bioinformatics Initiative of Osaka University Graduate School of Medicine, Osaka University

Nakajima Foundation Fellowship the Masason Foundation

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/s41591-020-0785-8.pdf

Reference49 articles.

1. Khera, A. V. et al. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat. Genet. 50, 1219–1224 (2018).

2. The All of Us Research Program Investigators. The “All of Us” Research Program. N. Engl. J. Med. 381, 668–676 (2019).

3. Torkamani, A., Wineinger, N. E. & Topol, E. J. The personal and clinical utility of polygenic risk scores. Nat. Rev. Genet. 19, 1–10 (2018).

4. Mahajan, A. et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat. Genet. 50, 1505–1513 (2018).

5. Schumacher, F. R. et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Nat. Genet. 50, 928–936 (2018).

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