Small RNAs break out: the molecular cell biology of mobile small RNAs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm3840.pdf
Reference117 articles.
1. Dunoyer, P. et al. Small RNA duplexes function as mobile silencing signals between plant cells. Science 328, 912–916 (2010). Shows for the first time that 21-nt-long siRNA duplexes are responsible for RNAi spreading over short distances in plants.
2. Molnar, A. et al. Small silencing RNAs in plants are mobile and direct epigenetic modification in recipient cells. Science 328, 872–875 (2010). Demonstrates an elegant combination of grafting and deep sequencing, which shows that 24-nt-long siRNAs are responsible for transmitting RNAi effects over long distances through the phloem.
3. Dunoyer, P. et al. An endogenous, systemic RNAi pathway in plants. EMBO J. 29, 1699–1712 (2010).
4. Melnyk, C. W., Molnar, A., Bassett, A. & Baulcombe, D. C. Mobile 24 nt small RNAs direct transcriptional gene silencing in the root meristems of Arabidopsis thaliana. Curr. Biol. 21, 1678–1683 (2011).
5. Winston, W. M., Molodowitch, C. & Hunter, C. P. Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. Science 295, 2456–2459 (2002). The first molecular characterization of a C. elegans protein that is specifically required for RNAi spreading.
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