Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Link
https://www.nature.com/articles/s41569-023-00872-4.pdf
Reference10 articles.
1. Sharman Moser, S. et al. The association between factor XI deficiency and the risk of bleeding, cardiovascular, and venous thromboembolic events. Thromb. Haemost. 122, 808–817 (2022).
2. Hsu, C., Hutt, E., Bloomfield, D. M., Gailani, D. & Weitz, J. I. Factor XI inhibition to uncouple thrombosis from hemostasis: JACC review topic of the week. J. Am. Coll. Cardiol. 78, 625–631 (2021).
3. Büller, H. R. et al. Factor XI antisense oligonucleotide for prevention of venous thrombosis. N. Engl. J. Med. 372, 232–240 (2015).
4. Visser, M., Heitmeier, S., Ten Cate, H. & Spronk, H. M. H. Role of factor XIa and plasma kallikrein in arterial and venous thrombosis. Thromb. Haemost. 120, 883–993 (2020).
5. Piccini, J. P. et al. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study. Lancet 399, 1383–1390 (2022).
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