Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content-Reference-Cited by-同舟云学术

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Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content

Published:2013-07 Issue:7 Volume:2 Page:59
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT: Pharmacometrics & Systems Pharmacology

Author:

Emoto C¹,Fukuda T¹²,Cox S¹,Christians U³,Vinks AA¹²⁴

Affiliation:

1. Division of Clinical Pharmacology; Cincinnati Children's Hospital Medical Center; Cincinnati Ohio USA

2. Department of Pediatrics, College of Medicine; University of Cincinnati; Cincinnati Ohio USA

3. iC42 Integrated Solutions in Clinical Research and Development, University of Colorado; Aurora Colorado USA

4. Department of Pharmacology & Cell Biophysics, College of Medicine; University of Cincinnati; Cincinnati Ohio USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2013.33/fullpdf

Reference40 articles.

1. mTOR signaling in growth control and disease;Laplante;Cell,2012

2. Transplantation: mTOR inhibition in kidney transplant recipients;Yost;Nat. Rev. Nephrol.,2011

3. Everolimus plus octreotide long-acting repeatable for the treatment of advanced neuroendocrine tumours associated with carcinoid syndrome (RADIANT-2): a randomised, placebo-controlled, phase 3 study;Pavel;Lancet,2011

4. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus;MacDonald;Clin. Ther.,2000

5. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD;Jacobsen;Transplant. Proc.,2001

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