Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities-Reference-Cited by-同舟云学术

Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities

Published:2011-08-03 Issue:10 Volume:31 Page:1986-1998
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Zanotti-Fregonara Paolo¹,Chen Kewei²³,Liow Jeih-San¹,Fujita Masahiro¹,Innis Robert B¹

Affiliation:

1. Molecular Imaging Branch, NIMH, NIH, Bethesda, Maryland, USA

2. Banner Alzheimer's Institute and Banner Good Samaritan PET Center, Phoenix, Arizona, USA

3. Department of Mathematics and Statistics, Arizona State University, Tempe, Arizona, USA

Abstract

Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2011.107

Reference87 articles.

1. Parametrically defined cerebral blood vessels as non-invasive blood input functions for brain PET studies

2. Noninvasive quantification of 18F-FLT human brain PET for the assessment of tumour proliferation in patients with high-grade glioma

3. Pharmacokinetic Assessment of the Uptake of 16β-18F-Fluoro-5α-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET

4. [18F]Galacto-RGD Positron Emission Tomography for Imaging of αvβ3 Expression on the Neovasculature in Patients with Squamous Cell Carcinoma of the Head and Neck

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