The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit-Reference-Cited by-同舟云学术

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The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Published:2009-02-04 Issue:7240 Volume:458 Page:914-918
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Dias Alexandre,Bouvier Denis,Crépin Thibaut,McCarthy Andrew A.,Hart Darren J.,Baudin Florence,Cusack Stephen,Ruigrok Rob W. H.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature07745.pdf

Reference30 articles.

1. Plotch, S. J., Bouloy, M., Ulmanen, I. & Krug, R. M. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 23, 847–858 (1981)

2. Li, M. L., Rao, P. & Krug, R. M. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J. 20, 2078–2086 (2001)

3. Fechter, P. et al. Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding. J. Biol. Chem. 278, 20381–20388 (2003)

4. Guilligay, D. et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nature Struct. Mol. Biol. 15, 500–506 (2008)

5. Shi, L., Summers, D. F., Peng, Q. & Galarz, J. M. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 208, 38–47 (1995)

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