A highly efficient cocaine-detoxifying enzyme obtained by computational design-Reference-Cited by-同舟云学术

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A highly efficient cocaine-detoxifying enzyme obtained by computational design

Published:2014-03-18 Issue:1 Volume:5 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Zheng Fang,Xue Liu,Hou Shurong,Liu Junjun,Zhan Max,Yang Wenchao,Zhan Chang-Guo

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms4457.pdf

Reference52 articles.

1. Quinn, D. M. Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states. Chem. Rev. 87, 955–979 (1987).

2. Baker, D. An exciting but challenging road ahead for computational enzyme design. Protein Sci. 19, 1817–1819 (2010).

3. Jiang, L. et al. De novo computational design of retro-aldol enzymes. Science 319, 1387–1391 (2008).

4. Röthlisberger, D. et al. Kemp elimination catalysts by computational enzyme design. Nature 453, 190–195 (2008).

5. Murphy, P. M., Bolduc, J. M., Gallaher, J. L., Stoddard, B. L. & Baker, D. Alteration of enzyme specificity by computational loop remodeling and design. Proc. Natl Acad. Sci. USA 106, 9215–9220 (2009).

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