Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical)
Link
https://www.nature.com/articles/s41582-022-00642-9.pdf
Reference134 articles.
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3. Bateman, R. et al. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease. N. Engl. J. Med. 367, 795–804 (2012).
4. McDade, E. et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology 91, e1295–e1306 (2018).
5. Riley, K. P., Snowdon, D., Desrosiers, M. & Markesbery, W. Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol. Aging 26, 341–347 (2005). This was was one of the first studies to show a dissociation between AD neuropathological lesions and symptoms; up to 12% of participants with intact cognition at the time of death had abundant Aβ plaques and neurofibrillary tangles at post mortem examination.
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