Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes-Reference-Cited by-同舟云学术

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes

Published:2005-08-14 Issue:9 Volume:23 Page:1171-1176
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Menzella Hugo G,Reid Ralph,Carney John R,Chandran Sunil S,Reisinger Sarah J,Patel Kedar G,Hopwood David A,Santi Daniel V

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt1128.pdf

Reference30 articles.

1. Walsh, C . Antibiotics: Actions, Origins, Resistance (ASM Press, Washington, DC, 2003).

2. Cortes, J., Haydock, S.F., Roberts, G.A., Bevitt, D.J. & Leadlay, P.F. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea. Nature 348, 176–178 (1990).

3. Reeves, C.D. The enzymology of combinatorial biosynthesis. Crit. Rev. Biotechnol. 23, 95–147 (2003).

4. Tsuji, S.Y., Cane, D.E. & Khosla, C. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. Biochemistry 40, 2326–2331 (2001).

5. Gokhale, R.S., Tsuji, S.Y., Cane, D.E. & Khosla, C. Dissecting and exploiting intermodular communication in polyketide synthases. Science 284, 482–485 (1999).

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