FASN activity is important for the initial stages of the induction of senescence
Author:
Funder
CHILDREN with CANCER UK
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology
Link
http://www.nature.com/articles/s41419-019-1550-0.pdf
Reference53 articles.
1. Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513–522 (2005).
2. Munoz-Espin, D. & Serrano, M. Cellular senescence: from physiology to pathology. Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014).
3. Rapisarda, V. et al. Integrin beta 3 regulates cellular senescence by activating the TGF-beta pathway. Cell Rep. 18, 2480–2493 (2017).
4. Hoare, M. et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat. Cell Biol. 18, 979–992 (2016).
5. Takahashi, A. et al. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells. Nat. Commun. 8, 15287 (2017).
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