Knockouts model the 100 best-selling drugs—will they model the next 100?

Author:

Zambrowicz Brian P.,Sands Arthur T.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Reference115 articles.

1. Drews, J. Biotechnology's metamorphosis into a drug discovery industry. Nature Biotechnol. 16, (Suppl) 22–24 (1998).

2. Hopkins, A. L. & Groom, C. R. The druggable genome. Nature Rev. Drug Discov. 1, 727–30 (2002). This paper describes the gene families that constitute the druggable genome from the perspective of chemists in the pharmaceutical industry.

3. PharmaLive.com . The Med Ad News 200- the world's best-selling medicines, May 2002. Engel Publishing Partners, Reprinted with permission from Med Ad News, (May 2002) ( PharmaLive.com , West Trenton, NJ, 2002). This is a list of the top 200 selling pharmaceutical drugs of the year 2001.

4. FDA. FDA. (Center for Drug Evaluation and Research, Rockville, MD, CDER Report to the Nation, 1997– 2001). The annual CDER Report to the Nation describes the new molecular entities that have been approved by the FDA each year.

5. Vinson, M. C., Davis, W. M. & Waters, I. W. (Drug Topics, Montvale, NJ, New Drug Approvals of 1995–1997). Each year, Drug Topics publishes a review of the new drugs approved by the FDA and their mechanism of action.

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