A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease-Reference-Cited by-同舟云学术

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Published:2011-01-30 Issue:3 Volume:43 Page:242-245
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Brest Patrick,Lapaquette Pierre,Souidi Mouloud,Lebrigand Kevin,Cesaro Annabelle,Vouret-Craviari Valérie,Mari Bernard,Barbry Pascal,Mosnier Jean-François,Hébuterne Xavier,Harel-Bellan Annick,Mograbi Baharia,Darfeuille-Michaud Arlette,Hofman Paul

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng.762.pdf

Reference24 articles.

1. McCarroll, S.A. et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat. Genet. 40, 1107–1112 (2008).

2. Prescott, N.J. et al. Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. Hum. Mol. Genet. 19, 1828–1839 (2010).

3. Bekpen, C. et al. Death and resurrection of the human IRGM gene. PLoS Genet. 5, e1000403 (2009).

4. Parkes, M. et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 39, 830–832 (2007).

5. Brest, P. et al. Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer. Curr. Mol. Med. 10, 486–502 (2010).

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