iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation and dismal outcome

Author:

Xie WeiORCID,Xu JieORCID,Hu ShiminORCID,Li ShaoyingORCID,Wang Wei,Cameron Yin C.,Toruner Gokce,Tang ZhenyaORCID,Medeiros L. Jeffrey,Tang Guilin

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Reference28 articles.

1. Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C. New mechanisms of AML1 gene alteration in hematological malignancies. Leukemia. 2003;17:9–16.

2. Streubel B, Valent P, Lechner K, Fonatsch C. Amplification of the AML1(CBFA2) gene on ring chromosomes in a patient with acute myeloid leukemia and a constitutional ring chromosome 21. Cancer Genet Cytogenet. 2001;124:42–6.

3. Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, et al. TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis. Leukemia. 1995;9:1985–9.

4. McLean TW, Ringold S, Neuberg D, Stegmaier K, Tantravahi R, Ritz J, et al. TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia. Blood. 1996;88:4252–8.

5. Swerdlow SH CE, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed; 2017.

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