Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants

Author:

Zubair H,Khan H Y,Sohail A,Azim S,Ullah M F,Ahmad A,Sarkar F H,Hadi S M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Cell Biology,Cellular and Molecular Neuroscience,Immunology

Reference45 articles.

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2. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004; 25: 857–866.

3. Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK . In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 2003; 22: 107–113.

4. Worthen DR, Ghosheh OA, Crooks PA . The in vitro anti-tumor activity of some crude and purified components of blackseed Nigella sativa L. Anticancer Res 1998; 18: 1527–1532.

5. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM . Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 2002; 20: 143–151.

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