Abstract
AbstractThe synaptic-tagging-and-capture (STC) hypothesis formulates that at each synapse the concurrence of a tag with protein synthesis yields the maintenance of changes induced by synaptic plasticity. This hypothesis provides a biological principle underlying the synaptic consolidation of memories that is not verified for recurrent neural circuits. We developed a theoretical model integrating the mechanisms underlying the STC hypothesis with calcium-based synaptic plasticity in a recurrent spiking neural network. In the model, calcium-based synaptic plasticity yields the formation of strongly interconnected cell assemblies encoding memories, followed by consolidation through the STC mechanisms. Furthermore, we show for the first time that STC mechanisms modify the storage of memories such that after several hours memory recall is significantly improved. We identify two contributing processes: a merely time-dependent passive improvement, and an active improvement during recall. The described characteristics can provide a new principle for storing information in biological and artificial neural circuits.
Funder
Deutsche Forschungsgemeinschaft
EC | Horizon 2020 Framework Programme
Publisher
Springer Science and Business Media LLC
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference101 articles.
1. Dudai, Y. The neurobiology of consolidation, or, how stable is the engram? Annu. Rev. Psychol. 55, 51–86 (2004).
2. Gluck, M. A., Mercado, E. & Myers, C. E. Learning and Memory: From Brain to Behavior 3rd edn (Worth Publishers, 2016).
3. Eichenbaum, H. The Cognitive Neuroscience of Memory: an Introduction 2nd edn (Oxford University Press, 2011).
4. Eichenbaum, H. Barlow versus Hebb: When is it time to abandon the notion of feature detectors and adopt the cell assembly as the unit of cognition? Neurosci. Lett. 680, 88–93 (2017).
5. Hebb, D. O. The Organization of Behavior 1st edn (Wiley, 1949).
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