A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
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Published:2024-01-09
Issue:1
Volume:7
Page:
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ISSN:2399-3642
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Container-title:Communications Biology
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language:en
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Short-container-title:Commun Biol
Author:
Li ShaoboORCID, Spitz NataliaORCID, Ghantous Akram, Abrishamcar SarinaORCID, Reimann Brigitte, Marques Irene, Silver Matt J.ORCID, Aguilar-Lacasaña Sofía, Kitaba NegusseORCID, Rezwan Faisal I.ORCID, Röder StefanORCID, Sirignano Lea, Tuhkanen Johanna, Mancano Giulia, Sharp Gemma C., Metayer Catherine, Morimoto LibbyORCID, Stein Dan J.ORCID, Zar Heather J., Alfano RossellaORCID, Nawrot Tim, Wang Congrong, Kajantie EeroORCID, Keikkala Elina, Mustaniemi SannaORCID, Ronkainen JustiinaORCID, Sebert SylvainORCID, Silva WnurinhamORCID, Vääräsmäki Marja, Jaddoe Vincent W. V.ORCID, Bernstein Robin M., Prentice Andrew M.ORCID, Cosin-Tomas Marta, Dwyer TerenceORCID, Håberg Siri Eldevik, Herceg Zdenko, Magnus Maria C., Munthe-Kaas Monica Cheng, Page Christian M., Völker Maja, Gilles Maria, Send Tabea, Witt StephanieORCID, Zillich LeaORCID, Gagliardi Luigi, Richiardi Lorenzo, Czamara DarinaORCID, Räikkönen Katri, Chatzi Lida, Vafeiadi MarinaORCID, Arshad S. Hasan, Ewart Susan, Plusquin Michelle, Felix Janine F.ORCID, Moore Sophie E., Vrijheid MartineORCID, Holloway John W.ORCID, Karmaus WilfriedORCID, Herberth GundaORCID, Zenclussen AnaORCID, Streit FabianORCID, Lahti JariORCID, Hüls Anke, Hoang Thanh T.ORCID, London Stephanie J.ORCID, Wiemels Joseph L.ORCID
Abstract
AbstractHigher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences U.S. Department of Health & Human Services | NIH | National Cancer Institute U.S. Environmental Protection Agency
Publisher
Springer Science and Business Media LLC
Reference61 articles.
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