Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2-Reference-Cited by-同舟云学术

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Published:2024-02-19 Issue:1 Volume:7 Page:
ISSN:2399-3642
Container-title:Communications Biology
language:en
Short-container-title:Commun Biol

Author:

Pérez-Jurado Luis A.^ORCID,Cáceres Alejandro^ORCID,Balagué-Dobón Laura^ORCID,Esko Tonu,López de Heredia Miguel^ORCID,Quintela Inés,Cruz Raquel^ORCID,Lapunzina Pablo^ORCID,Carracedo Ángel, ,Abellán Javier,Acosta-Isaac René,Aguado Jose María,Aguilar Carlos,Aguilera-Albesa Sergio,Ahmadi Sabbagh Abdolah,Alba Jorge,Albu Sergiu,Alcalá-Gallardo Karla A. M.,Alcoba-Florez Julia,Alcolea Batres Sergio,Algarin-Lara Holmes Rafael,Almadana Virginia,Medeiros Kelliane A.,Almeida Julia,Almoguera Berta,Alonso María R.,Álvarez Nuria,Álvarez-Sala Walther Rodolfo,Álvarez-Benítez Yady,Álvarez-Navia Felipe,dos Santos Katiusse A.,Andreu-Bernabeu Álvaro,Antonijoan Maria Rosa,Martínez-Aquino Eleno,Arana-Arri Eunate,Aranda Carlos,Arango Celso,Araque Carolina,Araujo Nathalia K.,Arcanjo Ana C.,Arnaiz Ana,Arnalich Fernández Francisco,Arranz María J.,Arribas López José Ramón,Artiga Maria-Jesús,Avello-Malaver Yubelly,Ayuso Carmen,Ballina Martín Belén,Baptista-Rosas Raúl C.,Baldion Ana María,Barranco-Díaz Andrea,Barreda-Sánchez María,Barrera-Penagos Viviana,Belhassen-Garcia Moncef,Bernal-Bello David,Bernal Enrique,Bezerra Joao F.,Bezerra Marcos A. C.,Blanca-López Natalia,Blancas Rafael,Boix-Palop Lucía,Borobia Alberto,Bravo Elsa,Brion María,Brochado-Kith Óscar,Brugada Ramón,Bustos Matilde,Cabello Alfonso,Cáceres-Agra Juan J.,Calbo Esther,Calderón Enrique J.,Camacho Shirley,Ceballos Francisco C.,Cañadas Yolanda,Carbonell Cristina,Cardona-Huerta Servando,Sánchez-Carpintero Abad María,Carpio Segura Carlos,Carrillo-Avila José Antonio,Campos Marcela C.,Casasnovas Carlos,Castaño Luis,Castaño Carlos F.,Castelao Jose E.,Castellano Candalija Aranzazu,Castillo María A.,Chaves-Santiago Walter G.,Chiquillo-Gómez Sylena,Cid-López Marco A.,Cienfuegos-Jiménez Óscar,Conde-Vicente Rosa,Cunha Gabriela C. R.,Cordero-Lorenzana M. Lourdes,Corella Dolores,Corrales Almudena,Cortés-Sánchez Jose L.,Corton Marta,Souza Karla S. C.,Silva Fabiola T. C.,Cuesta Luisa,Tavares Nathali A. C.,Carvalho Maria C. C.,Dalmau David,Dantas-Komatsu Raquel C. S.,Darnaude M. Teresa,de Andrés Raimundo,de Juan Carmen,de la Cruz Troca Juan J.,de la Horra Carmen,de la Hoz Ana B.,De Martino-Rodríguez Alba,Cruz Marina S.,de Sousa Alves Neri Julianna Lys,del Campo-Pérez Victor,Delgado-Cuesta Juan,Diaz de Bustamante Aranzazu,Díaz-Pérez Anderson,Dietl Beatriz,Diz-de Almeida Silvia,do Monte Alves Manoella,Domínguez-Garrido Elena,Rosa Lidia S.,Luchessi Andre D.,Echave-Sustaeta Jose,Eiros Rocío,Enciso-Olivera César O.,Escudero Gabriela,España Pedro Pablo,Estigarribia Sanabria Gladys,Fariñas María Carmen,Fernández Ramón,Fernández-Caballero Lidia,Fernández-Cruz Ana,Fernández-Ferrero Silvia,Fernández Martínez Yolanda,Fernandez-Nestosa María J.,Fernández-Robelo Uxía,Fernández-Rodríguez Amanda,Fernández-Sampedro Marta,Fernández Ruth,Fernández-Villa Tania,Fernández-Capitán Carmen,Carioca Antonio Augusto F.,Flores-Pérez Patricia,Fuenmayor-Hernández Lácides,Fuertes-Núñez Marta,Fumadó Victoria,Gadea Ignacio,Gagliardi Lidia,Gago-Domínguez Manuela,Gallego Natalia,Galoppo Cristina,García-Soidán Ana,García-Cerrada Carlos,García-de-Vicuña Aitor,Garcia-García Josefina,García-García Irene,García-Ibarbia Carmen,García-Montero Andrés C.,García Leticia,García Mercedes,García Torrejón María Carmen,García Inés,García-Vázquez Elisa,Garza-Frias Emiliano,Gentile Angela,Gil-Fournier Belén,de Araújo Jéssica N. G.,Gómez-Duque Mario,Gómez-Arrue Javier,Gómez Carrera Luis,Gómez García María,Gómez Sacristán Ángela,González Juan R.,González-Neira Anna,González Álvarez Beatriz,González Bernaldo de Quirós Fernán,González-Montelongo Rafaela,González-Peñas Javier,Gonzalez-Sagrado Manuel,Gonzalo-Benito Hugo,Gorgojo-Galindo Oscar,Górgolas Miguel,Guaragna Florencia,Chaux Jessica G.,Guillén-Navarro Encarna,Guillén-Guío Beatriz,Guisado-Vasco Pablo,Gutiérrez-Castañeda Luz D.,Gutiérrez-Bautista Juan F.,Heili-Frades Sara,Jacomo Rafael H.,Hernández Estefania,Hernández-Moro Cristina,Hernández-Ortega Luis D.,Hernández-Pérez Guillermo,Hernández-Vaquero Rebeca,Herráez Belén,Herranz M. Teresa,Herrera María,Herrero María José,Herrero-González Antonio,Horcajada Juan P.,Imaz-Ayo Natale,Intxausti-Urrutibeaskoa Maider,Íñigo-Campos Antonio,Íñiguez María,Jara Rubén,Jiménez Ángel,Jiménez-Alfaro Ignacio,Jiménez Pilar,Jiménez-Sousa María A.,Jordan Iolanda,Laguna-Goya Rocío,Laorden Daniel,Lasa-Lázaro María,Lattig María Claudia,Lauriente Ailen,Liger Borja Anabel,Llanos Lucía,López-Bernús Amparo,López de Heredia Miguel,Lopez-Garcia Esther,López-Granados Eduardo,Lopez-Rodriguez Rosario,López-Ruz Miguel A.,Lorente Leonardo,Lorenzo-Salazar José M.,Lozano José E.,Lozano-Espinosa María,Mahillo Ignacio,Mancebo Esther,Mar Carmen,Marcelo Calvo Cristina,Marcos-Delgado Alba,Marcos Miguel,Marín-Candón Alicia,Mariscal-Aguilar Pablo,Martin-Pedraza Laura,Martin-Fernandez Marta,Martín-López Caridad,Martín-Oterino José-Ángel,Martín María Dolores,Martín Vicente,Martín María M.,Martín-Vicente María,Martinez Amalia,Martínez-González Óscar,Martínez Ricardo,Martinez-Paz Pedro,Díaz-Caneja Covadonga M.,Martínez-Nieto Óscar,Martínez-López Iciar,Martínez-Reséndez Michel F.,Martínez Silvia,Martínez Juan José,Martínez-Pérez Ángel,Martínez-Ramas Andrea,Martínez-Robles Violeta,Marzal Laura,Mazzeu Juliana F.,Medrano Francisco J.,Meijome Xose M.,Mejuto-Montero Natalia,Mendes Ingrid,Duarte Alice L.,Méndez-Echevarría Ana,Mendoza Charris Humberto,Merayo Macías Eleuterio,Mercadillo Fátima,Mercado-Sesma Arieh R.,Mínguez Pablo,Molina-Roldán Elena,Molina Antonio J. J.,Montoya Juan José,Pinho Susana M. T.,Moreira-Escriche Patricia,Morelos-Arnedo Xenia,Moreno Rocío,Moreno Cuerda Víctor,Moreno-Docón Antonio,Moreno-Escalante Junior,Moreno Fernández Alberto,Muñoz García Patricia,Neira Pablo,Nevado Julián,Nieto-Gañán Israel,Silbiger Vivian N.,Nuñez-Torres Rocío,Obrador-Hevia Antònia,Ocejo-Vinyals J. Gonzalo,Olivar Virginia,Oliveira Silviene F.,Ondo Lorena,Orfao Alberto,Ortega-Paino Eva,Ortega Luis,Ortiz-López Rocío,Ortiz-Flores Fernando,Oteo José A.,Pacheco Manuel,Pacheco-Miranda Fredy Javier,Padilla-Conejo Irene,Panadero-Fajardo Sonia,Parellada Mara,Pariente-Rodríguez Roberto,Friaza Vicente,Paz-Artal Estela,Peces-Barba Germán,Pedromingo Kus Miguel S.,Perales Celia,Santos Ney P. C.,Guegel Genilson P.,Pérez María Jazmín,Pérez Alexandra,Pérez-Matute Patricia,Pérez César,Pérez-de-Nanclares Gustavo,Pérez-García Felipe,Pérez Patricia,Pérez-Tomás M. Elena,Perucho Teresa,Pichardo Lisbeth A.,Ribeiro Adriana P.,Pinsach-Abuin Mel·lina,Pinzón Luz Adriana,Medeiros Jeane F. P.,Pita Guillermo,Pla-Juncà Francesc,Planas-Serra Laura,Pompa-Mera Ericka N.,Porras-Hurtado Gloria L.,Pujol Aurora,Quevedo-Chávez María Eugenia,Quijada Maria Angeles,Quintela Inés,Ramiro-León Soraya,Rascado Sedes Pedro,Nunes Joana F. R.,Recalde Delia,Recio-Fernández Emma,Resino Salvador,Sousa Renata R.,Rivadeneira-Chamorro Carlos S.,Roa-Agudelo Diana,Robelo Pardo Montserrat,Fernandes Marianne R.,Rodríguez-Hernández María A.,Rodriguez-Palmero Agustí,Rodríguez-Ruiz Emilio,Rodriguez Marilyn Johanna,Rodríguez-Artalejo Fernando,Rodríguez-Ferrer Marena,Rodríguez-Gallego Carlos,Rodríguez-García José A.,Maya Belén Rodríguez,Rodriguez-Nicolas Antonio,Rodríguez-Novoa German Ezequiel,Rodriguez-Urrego Paula A.,Rojo Federico,Romero-Coronado Andrea,Morilla Rubén,Rondón-García Filomeno,Rosales-Castillo Antonio,Rubio Cladelis,Olivera María Rubio,Ruiz-Cabello Francisco,Ruiz-Casares Eva,Ruiz-Cubillan Juan J.,Ruiz-Hornillos Javier,Ruiz Montserrat,Ryan Pablo,Salamanca Hector D.,Salazar-García Lorena,Salgueiro-Origlia Giorgina Gabriela,Sangil Anna,Sánchez-Pernaute Olga,Sánchez Pedro-Luis,Sánchez López Antonio J.,Sánchez-Pablo Clara,Sánchez-Prados María Concepción,Sánchez-Real Javier,Sánchez-Redondo Jorge,Sancho-Sainz Cristina,Sande Esther,Santos Arnoldo,Schlüter Agatha,Segovia Sonia,Serra-Llovich Alex,Sevil-Puras Fernando,Sevilla-Porras Marta,Sicolo Miguel A.,Silván-Fuentes Cristina,Moraes Vitor M. S.,Souza Vanessa S.,Solé-Violán Jordi,Soria José Manuel,Sorlí Jose V.,Silva Nayara S.,Souto Juan Carlos,Sprockel John J.,Suárez-Rama José Javier,Suárez-Zamora David A.,Taboada-Fraga Xiana,Tamayo Eduardo,Tamayo-Velasco Alvaro,Taracido-Fernández Juan Carlos,Vasconcelos Romero H. T.,Tellería Carlos,Carratto Thássia M. T.,Tenorio-Castaño Jair Antonio,Teper Alejandro,Araujo Izabel M. T.,Torres-Macho Juan,Torres-Tobar Lilian,Torres-Gutiérrez Ronald P.,Troya Jesús,Urioste Miguel,Valencia-Ramos Juan,Valido Agustín,Vargas-Gallo Juan Pablo,Varón Belén,Vega Tomas,Velasco-Quirce Santiago,Vélez-Santamaría Valentina,Víctor Virginia,Vidán-Estévez Julia,Silva Gabriela V.,Vieitez-Santiago Miriam,Vilches Carlos,Villalobos Lavinia,Villar Felipe,Villar-Garcia Judit,Villaverde Cristina,Villoslada-Blanco Pablo,Virseda-Berdices Ana,Costa Tatiana X.,Yáñez Zuleima,Zapatero-Gaviria Antonio,Zarate Ruth,Zazo Sandra,Flores Carlos,Riancho José A.,Rojas-Martinez Augusto,González Juan R.^ORCID

Abstract

AbstractThe pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s42003-024-05805-6.pdf

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