On gene silencing by the X10-23 DNAzyme
Author:
Funder
Wellcome Trust
RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Subject
General Chemical Engineering,General Chemistry
Link
https://www.nature.com/articles/s41557-022-00990-5.pdf
Reference17 articles.
1. Wang, Y. J., Nguyen, K., Spitale, R. C. & Chaput, J. C. A biologically stable DNAzyme that efficiently silences gene expression in cells. Nat. Chem. https://doi.org/10.1038/s41557-021-00645-x (2021).
2. Nguyen, K., Wang, Y. J., England, W. E., Chaput, J. C. & Spitale, R. C. Allele-specific RNA knockdown with a biologically stable and catalytically efficient XNAzyme. J. Am. Chem. Soc. 143, 4519–4523 (2021).
3. Zhou, Y. F. & Zhou, C. Z. Nucleic acids designing in vivo active DNAzymes. Nat. Chem. 13, 299–301 (2021).
4. Taylor, A. I., Wan, J. K., Donde, M. J., Peak-Chew, S.-Y. & Holliger, P. A modular XNAzyme that cleaves long, structured RNAs under physiological conditions enables allele-specific gene silencing in cells. Nat. Chem. https://doi.org/10.1038/s41557-022-01021-z (in the press).
5. Santoro, S. W. & Joyce, G. F. A general purpose RNA-cleaving DNA enzyme. Proc. Natl Acad. Sci. USA 94, 4262–4266 (1997).
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