Impact of target interactions on small-molecule drug disposition: an overlooked area-Reference-Cited by-同舟云学术

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Impact of target interactions on small-molecule drug disposition: an overlooked area

Published:2018-02-23 Issue:4 Volume:17 Page:299-299
ISSN:1474-1776
Container-title:Nature Reviews Drug Discovery
language:en
Short-container-title:Nat Rev Drug Discov

Author:

van Waterschoot Robert A. B.,Parrott Neil J.,Olivares-Morales Andrés,Lavé Thierry,Rowland Malcolm,Smith Dennis A.

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology,General Medicine

Link

http://www.nature.com/articles/nrd.2018.26.pdf

Reference10 articles.

1. Morgan, P. et al. Impact of a five-dimensional framework on R&D productivity at AstraZeneca. Nat. Rev. Drug Discov. https://doi.org/10.1038/nrd.2017.244 (2018).

2. Smith, D. A., Di, L. & Kerns, E. H. The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery. Nat. Rev. Drug Discov. 9, 929–939 (2010).

3. Levy, G. Pharmacologic target–mediated drug disposition. Clin. Pharmacol. Ther. 56, 248–252 (1994).

4. An, G. Small-molecule compounds exhibiting target–mediated drug disposition (TMDD): a minireview. J. Clin. Pharmacol. 57, 131–136 (2017).

5. Peletier, L. A. & Gabrielsson, J. Pharmacokinetic steady-states highlight interesting target-mediated disposition properties. AAPS J. 19, 772–786 (2017).

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