IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors-Reference-Cited by-同舟云学术

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IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

Published:2013-04-21 Issue:5 Volume:19 Page:626-630
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Jameson Katherine L,Mazur Pawel K,Zehnder Ashley M,Zhang Jiajing,Zarnegar Brian,Sage Julien,Khavari Paul A

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.3165.pdf

Reference35 articles.

1. Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11–22 (2003).

2. McCormick, F. Cancer therapy based on oncogene addiction. J. Surg. Oncol. 103, 464–467 (2011).

3. Scholl, F.A. et al. MEK1/2 MAPK kinases are essential for mammalian development, homeostasis, and Raf-induced hyperplasia. Dev. Cell 12, 615–629 (2007).

4. Dumesic, P.A., Scholl, F.A., Barragan, D.I. & Khavari, P.A. ERK1/2 MAP kinases are required for epidermal G2/M progression. J. Cell Biol. 185, 409–422 (2009).

5. Nazarian, R. et al. Melanomas acquire resistance to B-RAFV600E inhibition by RTK or N-RAS upregulation. Nature 468, 973–977 (2010).

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