Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment-Reference-Cited by-同舟云学术

Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

Published:2023-01-02 Issue:8 Volume:41 Page:1160-1167
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Zhang Wei^ORCID,Oraiqat Ibrahim,Litzenberg Dale,Chang Kai-Wei^ORCID,Hadley Scott,Sunbul Noora Ba,Matuszak Martha M.,Tichacek Christopher J.,Moros Eduardo G.^ORCID,Carson Paul L.^ORCID,Cuneo Kyle C.^ORCID,Wang Xueding^ORCID,El Naqa Issam^ORCID

Abstract

AbstractIonizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive feedback for cancer treatments. We describe an iRAI volumetric imaging system that enables mapping of the three-dimensional (3D) radiation dose distribution in a complex clinical radiotherapy treatment. The method relies on a two-dimensional matrix array transducer and a matching multi-channel preamplifier board. The feasibility of imaging temporal 3D dose accumulation was first validated in a tissue-mimicking phantom. Next, semiquantitative iRAI relative dose measurements were verified in vivo in a rabbit model. Finally, real-time visualization of the 3D radiation dose delivered to a patient with liver metastases was accomplished with a clinical linear accelerator. These studies demonstrate the potential of iRAI to monitor and quantify the 3D radiation dose deposition during treatment, potentially improving radiotherapy treatment efficacy using real-time adaptive treatment.

Funder

U-M | Michigan Institute for Clinical and Health Research

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://www.nature.com/articles/s41587-022-01593-8.pdf

Reference48 articles.

1. Jaffray, D. A. & Gospodarowicz, M. K. in Cancer: Disease Control Priorities 3rd edn, Vol. 3 (eds Gelband, H. et al.) (The International Bank for Reconstruction and Development/The World Bank, 2015).

2. Liauw, S. L., Connell, P. P. & Weichselbaum, R. R. New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci. Transl. Med. 5, 173sr172 (2013).

3. Wambersie, A. ICRU Report 62, Prescribing, recording and reporting photon beam therapy (supplement to ICRU Report 50). ICRU News (1999).

4. ICRU Report 50. Prescribing, I. Recording and Reporting Photon Beam Therapy (International Commission on Radiation Units and Measurements, 1993).

5. Bucci, M. K., Bevan, A. & Roach, M. 3rd Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond. CA Cancer J. Clin. 55, 117–134 (2005).

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Resolution limits for radiation-induced acoustic imaging for in vivo radiation dosimetry;Physics in Medicine & Biology;2024-08-06

2. Imaging-guided companion diagnostics in radiotherapy by monitoring APE1 activity with afterglow and MRI imaging;Nature Communications;2024-07-28

3. Exosomal transfer of HCC-derived miR-17-5p downregulates NK cell function by targeting RUNX1-NKG2D axis;International Immunopharmacology;2024-07

4. X-Ray-Sensitizers: Organic Pharmaceutical Drug Intermediates Activated Directly by X-Rays to Efficiently Populate Triplet Excitons for Cancer Treatment;Engineering;2024-07

5. 4D in vivo dosimetry for a FLASH electron beam using radiation-induced acoustic imaging;Physics in Medicine & Biology;2024-05-31