Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Author:

Köttgen Anna, ,Albrecht Eva,Teumer Alexander,Vitart Veronique,Krumsiek Jan,Hundertmark Claudia,Pistis Giorgio,Ruggiero Daniela,O'Seaghdha Conall M,Haller Toomas,Yang Qiong,Tanaka Toshiko,Johnson Andrew D,Kutalik Zoltán,Smith Albert V,Shi Julia,Struchalin Maksim,Middelberg Rita P S,Brown Morris J,Gaffo Angelo L,Pirastu Nicola,Li Guo,Hayward Caroline,Zemunik Tatijana,Huffman Jennifer,Yengo Loic,Zhao Jing Hua,Demirkan Ayse,Feitosa Mary F,Liu Xuan,Malerba Giovanni,Lopez Lorna M,van der Harst Pim,Li Xinzhong,Kleber Marcus E,Hicks Andrew A,Nolte Ilja M,Johansson Asa,Murgia Federico,Wild Sarah H,Bakker Stephan J L,Peden John F,Dehghan Abbas,Steri Maristella,Tenesa Albert,Lagou Vasiliki,Salo Perttu,Mangino Massimo,Rose Lynda M,Lehtimäki Terho,Woodward Owen M,Okada Yukinori,Tin Adrienne,Müller Christian,Oldmeadow Christopher,Putku Margus,Czamara Darina,Kraft Peter,Frogheri Laura,Thun Gian Andri,Grotevendt Anne,Gislason Gauti Kjartan,Harris Tamara B,Launer Lenore J,McArdle Patrick,Shuldiner Alan R,Boerwinkle Eric,Coresh Josef,Schmidt Helena,Schallert Michael,Martin Nicholas G,Montgomery Grant W,Kubo Michiaki,Nakamura Yusuke,Tanaka Toshihiro,Munroe Patricia B,Samani Nilesh J,Jacobs David R,Liu Kiang,D'Adamo Pio,Ulivi Sheila,Rotter Jerome I,Psaty Bruce M,Vollenweider Peter,Waeber Gerard,Campbell Susan,Devuyst Olivier,Navarro Pau,Kolcic Ivana,Hastie Nicholas,Balkau Beverley,Froguel Philippe,Esko Tõnu,Salumets Andres,Khaw Kay Tee,Langenberg Claudia,Wareham Nicholas J,Isaacs Aaron,Kraja Aldi,Zhang Qunyuan,Wild Philipp S,Scott Rodney J,Holliday Elizabeth G,Org Elin,Viigimaa Margus,Bandinelli Stefania,Metter Jeffrey E,Lupo Antonio,Trabetti Elisabetta,Sorice Rossella,Döring Angela,Lattka Eva,Strauch Konstantin,Theis Fabian,Waldenberger Melanie,Wichmann H-Erich,Davies Gail,Gow Alan J,Bruinenberg Marcel,Stolk Ronald P,Kooner Jaspal S,Zhang Weihua,Winkelmann Bernhard R,Boehm Bernhard O,Lucae Susanne,Penninx Brenda W,Smit Johannes H,Curhan Gary,Mudgal Poorva,Plenge Robert M,Portas Laura,Persico Ivana,Kirin Mirna,Wilson James F,Leach Irene Mateo,van Gilst Wiek H,Goel Anuj,Ongen Halit,Hofman Albert,Rivadeneira Fernando,Uitterlinden Andre G,Imboden Medea,von Eckardstein Arnold,Cucca Francesco,Nagaraja Ramaiah,Piras Maria Grazia,Nauck Matthias,Schurmann Claudia,Budde Kathrin,Ernst Florian,Farrington Susan M,Theodoratou Evropi,Prokopenko Inga,Stumvoll Michael,Jula Antti,Perola Markus,Salomaa Veikko,Shin So-Youn,Spector Tim D,Sala Cinzia,Ridker Paul M,Kähönen Mika,Viikari Jorma,Hengstenberg Christian,Nelson Christopher P,Meschia James F,Nalls Michael A,Sharma Pankaj,Singleton Andrew B,Kamatani Naoyuki,Zeller Tanja,Burnier Michel,Attia John,Laan Maris,Klopp Norman,Hillege Hans L,Kloiber Stefan,Choi Hyon,Pirastu Mario,Tore Silvia,Probst-Hensch Nicole M,Völzke Henry,Gudnason Vilmundur,Parsa Afshin,Schmidt Reinhold,Whitfield John B,Fornage Myriam,Gasparini Paolo,Siscovick David S,Polašek Ozren,Campbell Harry,Rudan Igor,Bouatia-Naji Nabila,Metspalu Andres,Loos Ruth J F,van Duijn Cornelia M,Borecki Ingrid B,Ferrucci Luigi,Gambaro Giovanni,Deary Ian J,Wolffenbuttel Bruce H R,Chambers John C,März Winfried,Pramstaller Peter P,Snieder Harold,Gyllensten Ulf,Wright Alan F,Navis Gerjan,Watkins Hugh,Witteman Jacqueline C M,Sanna Serena,Schipf Sabine,Dunlop Malcolm G,Tönjes Anke,Ripatti Samuli,Soranzo Nicole,Toniolo Daniela,Chasman Daniel I,Raitakari Olli,Kao W H Linda,Ciullo Marina,Fox Caroline S,Caulfield Mark,Bochud Murielle,Gieger Christian, , , ,

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Reference49 articles.

1. So, A. & Thorens, B. Uric acid transport and disease. J. Clin. Invest. 120, 1791–1799 (2010).

2. Zhu, Y., Pandya, B.J. & Choi, H.K. Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007–2008. Arthritis Rheum. 63, 3136–3141 (2011).

3. Arromdee, E., Michet, C.J., Crowson, C.S., O′Fallon, W.M. & Gabriel, S.E. Epidemiology of gout: is the incidence rising? J. Rheumatol. 29, 2403–2406 (2002).

4. Wallace, K.L., Riedel, A.A., Joseph-Ridge, N. & Wortmann, R. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J. Rheumatol. 31, 1582–1587 (2004).

5. Yoo, H.G. et al. Prevalence of insulin resistance and metabolic syndrome in patients with gouty arthritis. Rheumatol. Int. 31, 485–491 (2011).

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