Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”-Reference-Cited by-同舟云学术

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Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching”

Published:2002-08-05 Issue:9 Volume:20 Page:908-913
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Sarkar Casim A.,Lowenhaupt Ky,Horan Thomas,Boone Thomas C.,Tidor Bruce,Lauffenburger Douglas A.

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt725.pdf

Reference42 articles.

1. Lauffenburger, D.A., Fallon, E.M. & Haugh, J.M. Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. Chem. Biol. 5, R257–R263 (1998).

2. French, A.R., Tadaki, D.K., Niyogi, S.K. & Lauffenburger, D.A. Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J. Biol. Chem. 270, 4334–4340 (1995).

3. Cama, A. et al. Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base-pair deletion in exon 1 and a mutation substituting serine for asparagine 462. Hum. Genet. 95, 174–182 (1995).

4. Ebner, R. & Derynck, R. Epidermal growth factor and transforming growth factor-α: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul. 2, 599–612 (1991).

5. Waterman, H., Sabanai, I., Geiger, B. & Yarden, Y. Alternative intracellular routing of ErbB receptors may determine signaling potency. J. Biol. Chem. 273, 13819–13827 (1998).

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