Muscle wasting in disease: molecular mechanisms and promising therapies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd4467.pdf
Reference253 articles.
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3. Zhou, X. et al. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell 142, 531–543 (2010). This article demonstrates that targeting of the myostatin–activin pathway is a promising option in reducing cachexia and its associated morbidity.
4. Mitch, W. E. & Goldberg, A. L. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N. Engl. J. Med. 335, 1897–1905 (1996). This review first established the importance of excessive proteolysis by the UPS in diverse disease.
5. Lecker, S. H., Solomon, V., Mitch, W. E. & Goldberg, A. L. Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J. Nutr. 129, 227S–237S (1999).
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