Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells-Reference-Cited by-同舟云学术

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Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

Published:2022-05-26 Issue:6 Volume:54 Page:874-884
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Qin Kunhua,Huang Peng,Feng Ruopeng,Keller Cheryl A.^ORCID,Peslak Scott A.^ORCID,Khandros Eugene,Saari Megan S.,Lan Xianjiang,Mayuranathan Thiyagaraj,Doerfler Phillip A.^ORCID,Abdulmalik Osheiza^ORCID,Giardine Belinda^ORCID,Chou Stella T.^ORCID,Shi Junwei^ORCID,Hardison Ross C.^ORCID,Weiss Mitchell J.^ORCID,Blobel Gerd A.^ORCID

Funder

Pfizer

U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

DiGaetano family;St Jude Children’s Research Hospital Collaborative Research Consortium on Novel Gene Therapies for Sickle Cell Disease

Doris Duke Charitable Foundation

American Society of Hematology

Cooley’s Anemia Foundation

Assisi Foundation of Memphis

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-022-01076-1.pdf

Reference69 articles.

1. Orkin, S. H. Molecular medicine: found in translation. Med (N. Y.) 2, 122–136 (2021).

2. Menzel, S. et al. A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15. Nat. Genet. 39, 1197–1199 (2007).

3. Uda, M. et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia. Proc. Natl Acad. Sci. USA 105, 1620–1625 (2008).

4. Sankaran, V. G. et al. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science 322, 1839–1842 (2008).

5. Masuda, T. et al. Gene regulation: transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin. Science 351, 285–289 (2016).

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