Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3046.pdf
Reference117 articles.
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3. The 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061–1073 (2010).
4. Lander, E. S. Initial impact of the sequencing of the human genome. Nature 470, 187–197 (2011).
5. Manly, K. F., Nettleton, D. & Hwang, J. T. Genomics, prior probability, and statistical tests of multiple hypotheses. Genome Res. 14, 997–1001 (2004). This is a valuable review of the relationships between prior probability, statistical significance and false-discovery rates as they pertain to genome-wide analyses.
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