Pore-engineered nanoarchitectonics for cancer therapy

Abstract

AbstractNanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics with application targets for cancer therapy by combining basic descriptions and exemplifying therapy applications in this review. The initial two sections briefly summarize pore-engineered nanoarchitectonics basics according to classification based on (i) material porosity and (ii) material composition. Afterward, the main application-oriented section—designing mesoporous material for cancer therapy—is presented. Various types of drug delivery systems, including mesoporous nanoparticles as nanocarriers, endogenous stimuli-responsive drug delivery, exogenous stimuli-responsive drug delivery, and targeted drug delivery, are described. Importantly, the clinical translation of mesoporous materials is further discussed. Mesoporous materials are unique nanoparticles that offer a network of cavities as vehicles for drug nanocarriers. Regarding the developments that allow mesoporous nanoparticles to be broadly used in clinical settings, there are several challenges that should be solved for their clinical application. From a clinical perspective, there are tremendous processes in the development of mesoporous materials.