Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
https://www.nature.com/articles/s41434-023-00383-4.pdf
Reference104 articles.
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3. Lemon RN. The Cortical “Upper Motoneuron” in Health and Disease. Brain Sci. 2021;11:619.
4. Genc B, Jara JH, Sanchez SS, Lagrimas AKB, Gozutok O, Kocak N, et al. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Ther. 2022;29:178–92.
5. Thomsen GM, Gowing G, Latter J, Chen M, Vit JP, Staggenborg K, et al. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014;34:15587–600.
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