Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)-Reference-Cited by-同舟云学术

Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2)

Published:2023-11-04 Issue:6 Volume:24 Page:295-302
ISSN:1476-5470
Container-title:Genes & Immunity
language:en
Short-container-title:Genes Immun

Author:

Raja Aroosha,Kuiper Jonas J. W.^ORCID

Abstract

AbstractEndoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that confer resistance against lethal infectious diseases, but also increase the risk for autoimmune disorders. Identifying how ERAP2 influences susceptibility to these traits requires an understanding of the selective pressures that shaped and maintained allelic variation throughout human evolution. Our review discusses the genetic regulation of haplotypes and diversity in naturally occurring ERAP2 allotypes in the global population. We outline how these ERAP2 haplotypes evolved during human history and highlight the presence of Neanderthal DNA sequences in ERAP2 of modern humans. Recent evidence suggests that human adaptation during the last ~10,000 years and historic pandemics left a significant mark on the ERAP2 gene that determines susceptibility to infectious and inflammatory diseases today.

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Immunology

Link

https://www.nature.com/articles/s41435-023-00225-8.pdf

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