Neuropeptides in the Cerebral Circulation: Relevance to Headache-Reference-Cited by-同舟云学术

Neuropeptides in the Cerebral Circulation: Relevance to Headache

Published:1995-08 Issue:4 Volume:15 Page:272-276
ISSN:0333-1024
Container-title:Cephalalgia
language:en
Short-container-title:Cephalalgia

Author:

Edvinsson L,Goadsby PJ¹

Affiliation:

1. Institute of Neurology1, Queen Square, London, UK

Abstract

The article briefly describes the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gent-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilatation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.1995.1504272.x

Reference30 articles.

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