Affiliation:
1. Sechenov First Moscow State Medical University (Sechenov University)
2. Asfendiyarov Kazakh National Medical University
Abstract
Aim. Assessment of efficacy and the mechanism of action of gastrointestinal mucosa (GM) protection in current treatment settings with methylmethionine-sulfonium chloride (vitamin U) to illustrate its applicability in erosive ulcerative lesions of various aetiologies.Key points. Aside to damage prevention in exposure to aggressive agents, gastroprotection implies healing promotion under the preserved level of hydrochloric acid secretion. Prostaglandins (PG) and SH-antioxidants are key mediators of gastroprotection in acute and chronic damage. SH-containing endogenous substances (L-cysteine, D,L-methionine, GSH) and exogenous molecules (methylmethionine-sulfonium chloride (MMSC), N-acetylcysteine) prevent damage due to the ability to absorb/neutralise free radicals released in xenobiotic-triggered cell damage, inhibit TNF-α expression, reduce the aspirin-induced leukocyte-endothelium adhesion and stimulate mucin release. In experiment, MMSC prevented the ethanol-induced GM damage, stimulated mucin release and its redistribution on the GM surface; in clinical trials, MMSC effectively facilitated remission in duodenal ulcer.Conclusion. Preparations exerting a protective effect on gastroduodenal mucosa, such as methylmethionine-sulfonium chloride (vitamin U), may improve basic treatment settings and facilitate remission in erosive ulcerative lesions of upper gastrointestinal tract.
Publisher
Russian Gastroenterolgocial Society
Reference61 articles.
1. Ivashkin V.T., Mayev I.V., Lapina T.L., Sheptulin A.A., Trukhmanov A.S., Baranskaya Y.K., et al. Diagnostics and treatment of Helicobacter pylori infection in adults: Clinical guidelines of the Russian gastroenterological association. Rus J Gastroenterol Hepatol Coloproctol. 2018;28(1):55–70 (In Russ.). DOI: 10.22416/1382-4376-2018-28-1-55-70
2. Karateev A.E., Nasonov E.L., Ivashkin V.T., Martynov A.I., Yakhno N.N., Arutyunov G.P. et al. Rational use of nonsteroidal anti-inflammatory drugs. Clinical guidelines. Rheumatology Science and Practice. 2018;56:1–29. (In Russ.) DOI: 10.14412/1995-4484-2018-1-29
3. Nazarov V.E. Failures of eradication therapy unrelated to Helicobacter pylori antibiotic resistance and routes to their solution. RMJ. Medical Review. 2018. 26(3):4–12. (In Russ.).
4. Evseev M.A. NSAID-induced bleeding-complicated gastroduodenal ulcers. RMJ. 2006;15:1099–107. (In Russ.).
5. Shostak N.A., Ryabkova A.A., Savelyev V.S., and Malyarova L.P. Gastrointestinal bleeding as complication of NSAID-associated gastropathies. Terapevticheskiy archiv. 2003;5:70–4. (In Russ.).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献