Hexapeptide dalargin in clinical gastroenterology: 30 years' of clinical application of the drug

Abstract

Aim of review. To discuss results of application of the Russian drug dalargin in the treatment of gastroenterological diseases. Summary. Dalargin is the first synthetic opioid peptide agent created on the basis of endogenous leucineenkephaline. Pharmacological effects of dalargin are caused by opioid receptors. The pilot studies showed protective properties for ulceration and antisecretory effect. In therapeutic practice it is applied for treatment of peptic ulcer of the stomach and duodenum, acute and chronic pancreatitis and pancreatic necrosis. Article presents results of use of hexapeptide, algorithm and guideline on its application are analyzed, possible mechanisms of action are discussed. The therapeutic effect of dalargin at various gastro-intestinal diseases is determined by its bioregulator properties maintaining body homeostasis up to standard. Conclusion. Dalargin has demonstrated high therapeutic efficacy and safety for almost 30 years of application in practical gastroenterology and significantly expanded facilities of gastroenterologists in treatment of digestive diseases.