Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver-Reference-Cited by-同舟云学术

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Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Published:2011-11-02 Issue:2 Volume:40 Page:322-328
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Sanoh Seigo,Horiguchi Aya,Sugihara Kazumi,Kotake Yaichiro,Tayama Yoshitaka,Ohshita Hiroki,Tateno Chise,Horie Toru,Kitamura Shigeyuki,Ohta Shigeru

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference33 articles.

1. A Comparison of Pharmacokinetics between Humans and Monkeys

2. Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance

3. Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

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