Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs-Reference-Cited by-同舟云学术

Hepatic, Intestinal, Renal, and Plasma Hydrolysis of Prodrugs in Human, Cynomolgus Monkey, Dog, and Rat: Implications for In Vitro–In Vivo Extrapolation of Clearance of Prodrugs

Published:2014-07-03 Issue:9 Volume:42 Page:1522-1531
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Nishimuta Haruka,Houston J. Brian,Galetin Aleksandra

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference44 articles.

1. Species Difference of Esterase Expression and Hydrolase Activity in Plasma

2. Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

3. Relative Importance of Intestinal and Hepatic Glucuronidation—Impact on the Prediction of Drug Clearance

4. Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

5. Targeted prodrugs in oral drug delivery: the modern molecular biopharmaceutical approach

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