Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio-Reference-Cited by-同舟云学术

Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio

Published:2017-11-17 Issue:2 Volume:46 Page:89-99
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Obach R. Scott,Lin Jian,Kimoto Emi,Duvvuri Sridhar,Nicholas Timothy,Kadar Eugene P.,Tremaine Larry M.,Sawant-Basak Aarti

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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4. Qualitative Analysis of the Role of Metabolites in Inhibitory Drug−Drug Interactions: Literature Evaluation Based on the Metabolism and Transport Drug Interaction Database

5. Hepatic disposition of gemfibrozil and its major metabolite gemfibrozil 1-O-β-glucuronide;Kimoto;Mol Pharm,2015

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