Mechanistic Studies on Metabolic Interactions between Gemfibrozil and Statins

Author:

Prueksaritanont Thomayant,Zhao Jamie J.,Ma Bennett,Roadcap Brad A.,Tang Cuyue,Qiu Yue,Liu Lida,Lin Jiunn H.,Pearson Paul G.,Baillie Thomas A.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference39 articles.

1. Plasma concentrations of active simvastatin acid are increased by gemfibrozil

2. Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters.;Billecke;Drug Metab Dispos,2000

3. Metabolism of cerivastatin by human liver microsomes in vitro: characterization of primary metabolic pathways and cytochrome P450 isozymes involved.;Boberg;Drug Metab Dispos,1997

4. Biotransformation of cerivastatin in mice, rats and dogs in vivo.;Boberg;Drug Metab Dispos,1998

5. Metabolic disposition of simvastatin in patients with T-tube drainage.;Cheng;Drug Metab Dispos,1994

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