Metabolism and Mode of Inhibition of Varicella-Zoster Virus byl-β-5-Bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil Is Dependent on Viral Thymidine Kinase

Author:

Li Ling,Dutschman Ginger E.,Gullen Elizabeth A.,Tsujii Eisaku,Grill Susan P.,Choi Yongseok,Chu Chung K.,Cheng Yung-chi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference31 articles.

1. Comparative metabolism of E-5-(2-bromovinyl)-2′-deoxyuridine and 1-beta-d-arabinofuranosyl-E-5-(2-bromovinyl)uracil in herpes simplex virus-infected cells.;Ayisi;Mol Pharmacol,1987

2. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2 propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.;Balzarini;J Biol Chem,1993

3. Inhibitory activities of herpes simplex viruses type 1 and 2 and human cytomegalovirus by stereoisomers of 2′-deoxy-3′-oxa-5(E)-(2-bromovinyl)uridines and their 4′-thio analogues.

4. Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2′,3′-dideoxy-3′-thiacytidine in the inhibition of hepatitis B virus replication.;Chang;J Biol Chem,1992

5. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with anti-human immunodificiency virus compound 2′,3′-dideoxycytidine.;Cheng;J Biol Chem,1989

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