Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans-Reference-Cited by-同舟云学术

Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

Published:2009-09-24 Issue:1 Volume:332 Page:17-25
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Atack John R.,Wong Dean F.,Fryer Tim D.,Ryan Christine,Sanabria Sandra,Zhou Yun,Dannals Robert F.,Eng Wai-si,Gibson Raymond E.,Burns H. Donald,Vega Jose M.,Vessy Laura,Scott-Stevens Paul,Beech John S.,Baron Jean-Claude,Sohal Bindi,Schrag Michael L.,Aigbirhio Franklin I.,McKernan Ruth M.,Hargreaves Richard J.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference40 articles.

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4. The plasma-occupancy relationship of the novel GABAAreceptor benzodiazepine site ligand, α5IA, is similar in rats and primates

5. Atack JR Hallett D Tye S Wafford KA Ryan C Sanabria-Bohórquez SM Eng W Gibson RE Burns HD Dawson GR . (2009b) Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective agonist. J Psychopharmacol DOI:10.1177/0269881109354928 .

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