Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors-Reference-Cited by-同舟云学术

Constitutively Active Mutants of the Histamine H1 Receptor Suggest a Conserved Hydrophobic Asparagine-Cage That Constrains the Activation of Class A G Protein-Coupled Receptors

Published:2007-10-24 Issue:1 Volume:73 Page:94-103
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Bakker Remko A.,Jongejan Aldo,Sansuk Kamonchanok,Hacksell Uli,Timmerman Henk,Brann Mark R.,Weiner Dave M.,Pardo Leonardo,Leurs Rob

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference41 articles.

1. In Vitro Pharmacology of Clinically Used Central Nervous System-Active Drugs as Inverse H1 Receptor Agonists

2. Histamine H1-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gαq/11-Subunits in Constitutive and Agonist-Mediated Signaling

3. Constitutive activity of the histamine H1 receptor reveals inverse agonism of histamine H1 receptor antagonists

4. Functional Microdomains in G-protein-coupled Receptors

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