Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver-Reference-Cited by-同舟云学术

Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver

Published:2008-07-17 Issue:10 Volume:36 Page:2113-2120
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Kassner Nina,Huse Klaus,Martin Hans-Jörg,Gödtel-Armbrust Ute,Metzger Annegret,Meineke Ingolf,Brockmöller Jürgen,Klein Kathrin,Zanger Ulrich M.,Maser Edmund,Wojnowski Leszek

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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2. Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione,

3. An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

4. Higher activity of polymorphic NAD(P)H:quinone oxidoreductase in liver cytosols from blacks compared to whites

5. Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit

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